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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1990-2-13
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pubmed:abstractText |
In 3 patients with ANLL, chemotherapy including high or conventional doses of Ara-C had been ineffective. However subsequent treatment with low-dose (LD) Ara-C induced a PR or CR which were sustained with regular LD Ara-C reinduction courses. Survival of the 2 patients with PR was 24 and 8 months respectively. The patient with CR was alive 18 months after a bone marrow graft. In 2/3 cases, the cytogenetic abnormalities initially detected disappeared with treatment. These observations suggest that the cellular mechanism of action of LD Ara-C is different from that of HD Ara-C, but do not favour a differentiating action of LD Ara-C. LD Ara-C can be prescribed as a salvage therapy even after failure of high or conventional doses.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:author | |
pubmed:volume |
31
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
311-3
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2608442-Adult,
pubmed-meshheading:2608442-Bone Marrow,
pubmed-meshheading:2608442-Bone Marrow Transplantation,
pubmed-meshheading:2608442-Child,
pubmed-meshheading:2608442-Combined Modality Therapy,
pubmed-meshheading:2608442-Cytarabine,
pubmed-meshheading:2608442-Dose-Response Relationship, Drug,
pubmed-meshheading:2608442-Female,
pubmed-meshheading:2608442-Humans,
pubmed-meshheading:2608442-Leukemia, Myeloid, Acute,
pubmed-meshheading:2608442-Leukemia, Myelomonocytic, Acute,
pubmed-meshheading:2608442-Male,
pubmed-meshheading:2608442-Middle Aged,
pubmed-meshheading:2608442-Remission Induction
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pubmed:year |
1989
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pubmed:articleTitle |
Low-dose arabinosyl cytosine therapy of AML may be effective after failure of high or conventional doses.
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pubmed:affiliation |
Laboratoires d'Hématologie et de Cytogénétique, Hôpital Antoine Béclère, Clamart, France.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|