Linked Life Data

2608168

Source:http://linkedlifedata.com/resource/pubmed/id/2608168

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-2-12
pubmed:abstractText
Twenty patients: seven with herpes simplex virus encephalitis (HSVE), six with other severe central nervous system (CNS) infections and 7 with Rett syndrome were studied to determine whether they showed any intrathecal synthesis of virus-specific or total IgG in CNS. The study of the postinfectious patients was made a mean of 20 years after the primary infection in childhood. Four of seven patients with HSVE had an elevated IgG index and four showed intrathecal viral antibody production which was both specific (against HSV) and non-specific. One patient with congenital syphilis and one with tuberculotic meningitis showed non-specific intrathecal viral antibody synthesis. In three of seven patients with Rett syndrome intrathecal antibody production was observed. The clarification of the mechanism of polyclonal immunoactivation in postinfectious diseases would be of interest since similar persistent immunoactivation is a common feature in multiple sclerosis. In Rett syndrome the immunoactivation may also have pathogenetic significance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0174-304X
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-9
pubmed:dateRevised
2008-1-16
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Long-term persistence of intrathecal viral antibody responses in postinfectious diseases of the central nervous system and in Rett syndrome.
pubmed:affiliation
Department of Pediatrics, University Central Hospital of Turku, Finland.
pubmed:publicationType
Journal Article