Linked Life Data

2603162

Source:http://linkedlifedata.com/resource/pubmed/id/2603162

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-2-8
pubmed:abstractText
Urothelial carcinogenesis progresses through several morphologically identifiable stages from simple hyperplasia, to nodular and papillary hyperplasia, to papilloma, and to noninvasive and invasive carcinoma. Unfortunately, no specific identifiable markers on any of the early lesions are available to distinguish those which will become neoplasms from those that are potentially reversible. Urothelial toxicity secondary to cyclophosphamide injection also progresses through several phases, beginning with vacuolization of the epithelium, to necrosis and ulceration, followed by an inflammatory infiltrate, granulation tissue formation, and marked regenerative hyperplasia of the epithelium, with ultimate repair and return to normal. Numerous changes related to toxicity are similar to those seen during carcinogenesis. In addition, several apparent morphologic "changes" occurring in the adult bladder can be mistaken for evidence of toxicity, and more importantly, many of the changes seen during regenerative repair and during carcinogenesis occur in the normal fetal urothelial development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
484-98
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Toxic and nontoxic changes induced in the urothelium by xenobiotics.
pubmed:affiliation
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't