|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1990-2-1
|
|
pubmed:abstractText |
Staphylococcus aureus strains specifically resistant to cephamycin antibiotics have been found among recent clinical isolates. These strains formed penicillin-binding protein (PBP) 2' and became phenotypically resistant to methicillin after induction with cefoxitin. Other cephamycin-type antibiotics also induced methicillin-resistance, whereas non-cephamycin-type cephalosporins such as cefmenoxime and ceftizoxime did not do so. The clones that constitutively synthesized PBP 2' arose from the cephamycin-resistant strains at a frequency of 10(-5). They were indistinguishable from clinically isolated methicillin-resistant S. aureus (MRSA). Cephamycin-resistant S. aureus may be a source for emerging MRSA.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0305-7453
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
637-45
|
|
pubmed:dateRevised |
2004-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:2599989-Bacterial Proteins,
pubmed-meshheading:2599989-Carrier Proteins,
pubmed-meshheading:2599989-Cephamycins,
pubmed-meshheading:2599989-Culture Media,
pubmed-meshheading:2599989-Hexosyltransferases,
pubmed-meshheading:2599989-Methicillin,
pubmed-meshheading:2599989-Microbial Sensitivity Tests,
pubmed-meshheading:2599989-Muramoylpentapeptide Carboxypeptidase,
pubmed-meshheading:2599989-Penicillin Resistance,
pubmed-meshheading:2599989-Penicillin-Binding Proteins,
pubmed-meshheading:2599989-Peptidyl Transferases,
pubmed-meshheading:2599989-Staphylococcus aureus,
pubmed-meshheading:2599989-Temperature
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
Emergence of methicillin-resistant clones from cephamycin-resistant Staphylococcus aureus.
|
|
pubmed:affiliation |
Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
|
|
pubmed:publicationType |
Journal Article
|
