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pubmed-article:2598154pubmed:abstractTextLiposomes laden with radio-opaque agents (ROA) were prepared by the reverse phase evaporation method. The liposome solutions--containing 1.7-2.5 mg iodine per mg lipid--were injected into Wistar rats. 60 min post injection the rats were scanned in a Siemens CT scanner. Following the injection of 260 mg encapsulated iodine per kg bodyweight--less than half the iodine of the normal ROA bolus injection--there was a long lasting arise in liver enhancement of 40 Hounsfield units (HU). In animals with liver tumours induced by nitrosamine lesions of 2-3 mm in diameter could be detected.lld:pubmed
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pubmed-article:2598154pubmed:pagination455-62lld:pubmed
pubmed-article:2598154pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:2598154pubmed:articleTitleRadio-opaque liposomes for the improved visualisation of focal liver disease by computerized tomography.lld:pubmed
pubmed-article:2598154pubmed:affiliationDepartment for Gastroenterology and Hepatology, Medizinische Hochschule, Hannover.lld:pubmed
pubmed-article:2598154pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2598154pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed