|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1990-2-2
|
|
pubmed:abstractText |
Liposomes laden with radio-opaque agents (ROA) were prepared by the reverse phase evaporation method. The liposome solutions--containing 1.7-2.5 mg iodine per mg lipid--were injected into Wistar rats. 60 min post injection the rats were scanned in a Siemens CT scanner. Following the injection of 260 mg encapsulated iodine per kg bodyweight--less than half the iodine of the normal ROA bolus injection--there was a long lasting arise in liver enhancement of 40 Hounsfield units (HU). In animals with liver tumours induced by nitrosamine lesions of 2-3 mm in diameter could be detected.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0895-6111
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
455-62
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:2598154-Animals,
pubmed-meshheading:2598154-Contrast Media,
pubmed-meshheading:2598154-Diethylnitrosamine,
pubmed-meshheading:2598154-Female,
pubmed-meshheading:2598154-Iohexol,
pubmed-meshheading:2598154-Iothalamic Acid,
pubmed-meshheading:2598154-Ioxaglic Acid,
pubmed-meshheading:2598154-Liposomes,
pubmed-meshheading:2598154-Liver,
pubmed-meshheading:2598154-Liver Neoplasms, Experimental,
pubmed-meshheading:2598154-Rats,
pubmed-meshheading:2598154-Rats, Inbred Strains,
pubmed-meshheading:2598154-Tomography, X-Ray Computed,
pubmed-meshheading:2598154-Triiodobenzoic Acids
|
|
pubmed:articleTitle |
Radio-opaque liposomes for the improved visualisation of focal liver disease by computerized tomography.
|
|
pubmed:affiliation |
Department for Gastroenterology and Hepatology, Medizinische Hochschule, Hannover.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
