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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1990-1-11
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pubmed:abstractText |
At least two separate but interdependent events are required to attain autonomous growth as a consequence of ectopic expression of the multilineage colony-stimulating factor gene in hematopoietic progenitor cells. The rate at which the second event occurs is more than 3 orders of magnitude higher in precursor cell lines (FDC-P1 or FDC-P2) than in stem cell lines (FDC-Pmix). Autonomous, but not density-dependent, growth is tightly coupled to tumorigenicity in precursor cells; however, neither growth-factor-independent nor autonomously growing stem cell lines are tumorigenic.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-2467186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-2784443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-2829358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-2838175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-2990035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-2994046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-3039810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-3091439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-3314997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-3317408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-3491251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-3500094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-3878229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-6271971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-6417657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2586530-6968334
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5746-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2586530-Animals,
pubmed-meshheading:2586530-Cell Division,
pubmed-meshheading:2586530-Cell Line,
pubmed-meshheading:2586530-Cell Transformation, Neoplastic,
pubmed-meshheading:2586530-Colony-Stimulating Factors,
pubmed-meshheading:2586530-Gene Expression,
pubmed-meshheading:2586530-Genetic Vectors,
pubmed-meshheading:2586530-Hematopoietic Stem Cells,
pubmed-meshheading:2586530-Immune Sera,
pubmed-meshheading:2586530-Kinetics,
pubmed-meshheading:2586530-Mice,
pubmed-meshheading:2586530-Mutation
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pubmed:year |
1989
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pubmed:articleTitle |
Rates of mutation to growth factor autonomy and tumorigenicity differ in hematopoietic stem and precursor cells expressing the multilineage colony-stimulating factor gene.
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pubmed:affiliation |
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Universität Hamburg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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