| pubmed-article:2584372 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2584372 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2584372 | lifeskim:mentions | umls-concept:C0006819 | lld:lifeskim |
| pubmed-article:2584372 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:2584372 | lifeskim:mentions | umls-concept:C0016194 | lld:lifeskim |
| pubmed-article:2584372 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:2584372 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:2584372 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2584372 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:2584372 | pubmed:dateCreated | 1990-1-9 | lld:pubmed |
| pubmed-article:2584372 | pubmed:abstractText | We measured isotype-specific human antibodies directed against Campylobacter jejuni native flagellin and a synthetic peptide derived from the N-terminal amino acid sequence of the protein by using a microdilution enzyme-linked immunosorbent assay (ELISA). Serum samples from patients with gastrointestinal infection caused by C. jejuni (n = 20) and control samples (number from normal subjects = 20; number from patients with diarrhea other than campylobacter = 20) were tested in this assay. Serum specimens from patients with campylobacter infection showed statistically significant higher isotype-specific antiflagellin antibody titers than control samples did. Detection of immunoglobulin G (IgG) antibodies was less specific (70%) than detection of either IgA or IgM antibodies in infected patients (95%). The sensitivity of testing for any of the isotypes ranged from 64 to 100% in acute-phase serum specimens and 85 to 95% in convalescent-phase serum specimens. An ELISA with an N-terminal synthetic peptide derived from the flagellin protein as antigen was not sensitive (60%) for detecting campylobacter infection but was very specific (97.5%). In conclusion, detection of serum IgA or IgM against C. jejuni flagellin may be a useful marker of infection. Although the N-terminal synthetic peptide was antigenic in a few patients with infection and showed good specificity in the ELISA, additional amino acid sequences with better sensitivity for detecting infection need to be identified. | lld:pubmed |
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| pubmed-article:2584372 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2584372 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2584372 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2584372 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2584372 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2584372 | pubmed:issn | 0095-1137 | lld:pubmed |
| pubmed-article:2584372 | pubmed:author | pubmed-author:VeilSS | lld:pubmed |
| pubmed-article:2584372 | pubmed:author | pubmed-author:NachamkinII | lld:pubmed |
| pubmed-article:2584372 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2584372 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:2584372 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2584372 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2584372 | pubmed:pagination | 2195-8 | lld:pubmed |
| pubmed-article:2584372 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2584372 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2584372 | pubmed:articleTitle | Human antibody response to Campylobacter jejuni flagellin protein and a synthetic N-terminal flagellin peptide. | lld:pubmed |
| pubmed-article:2584372 | pubmed:affiliation | Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283. | lld:pubmed |
| pubmed-article:2584372 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2584372 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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