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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1989-12-29
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pubmed:abstractText |
The neuropeptide head activator (HA) acts as an autocrine growth factor for the neural cell line NH15-CA2. Cell proliferation is increased in the presence of HA and inhibited by HA peptide-specific antisera. Stimulation of cellular proliferation is visible 2 h after HA application as an increase in cells in mitosis. HA has no direct effect on stimulating DNA synthesis. HA thus functions as a control signal in the G2/mitosis transition and not in the G1/S transition. Receptors for HA are present on small round cells in clusters of foci and not on cells with differentiated morphology, suggesting cell-cycle-dependent HA receptor expression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-16453697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-2566917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-2577954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-2702688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-2707482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-284369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-2901043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-3076287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-3076289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-3215393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-3225643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-3877931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-3907660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-41246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-5076361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-6153398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-6688784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-6697993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-7290191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2583101-942051
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3311-8
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:2583101-Animals,
pubmed-meshheading:2583101-Binding Sites,
pubmed-meshheading:2583101-Cell Division,
pubmed-meshheading:2583101-Chromatography, High Pressure Liquid,
pubmed-meshheading:2583101-DNA,
pubmed-meshheading:2583101-Glioma,
pubmed-meshheading:2583101-Growth Substances,
pubmed-meshheading:2583101-Hybrid Cells,
pubmed-meshheading:2583101-Immunohistochemistry,
pubmed-meshheading:2583101-Interphase,
pubmed-meshheading:2583101-Mice,
pubmed-meshheading:2583101-Mitosis,
pubmed-meshheading:2583101-Neuroblastoma,
pubmed-meshheading:2583101-Neurons,
pubmed-meshheading:2583101-Neuropeptides,
pubmed-meshheading:2583101-Pyrrolidonecarboxylic Acid,
pubmed-meshheading:2583101-Rats,
pubmed-meshheading:2583101-Tumor Cells, Cultured
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pubmed:year |
1989
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pubmed:articleTitle |
Head activator acts as an autocrine growth factor for NH15-CA2 cells in the G2/mitosis transition.
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pubmed:affiliation |
Zentrum für Molekulare Biologie, Heidelberg, FRG.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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