| pubmed-article:2577287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2577287 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:2577287 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2577287 | lifeskim:mentions | umls-concept:C0108773 | lld:lifeskim |
| pubmed-article:2577287 | lifeskim:mentions | umls-concept:C1367475 | lld:lifeskim |
| pubmed-article:2577287 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:2577287 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:2577287 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2577287 | pubmed:dateCreated | 1991-3-22 | lld:pubmed |
| pubmed-article:2577287 | pubmed:abstractText | T cells can be divided into unprimed virgin (T0) and primed memory (T') subpopulations by their expression of different isoforms of the leukocyte common antigen. We have separated the CD4+ T cells into T0 and T' subpopulations and examined their capacity to respond to activation signals via the CD2 receptor molecule. On stimulation with a mitogenic combination of anti-CD2 antibodies, the T' population was induced to express IL-2 receptor, increased levels of the 4F2 antigen and to proliferate, whereas the response of the T0 populations was reflected solely by a minimal increase in the 4F2 antigen. The addition of IL-2 or monocytes to T0 cells stimulated with anti-CD2 antibodies did not enhance their expression of the IL-2 receptor or proliferation. However, T0 cells stimulated with the triad of anti-CD2 antibodies, monocytes, and IL-2 responded with high levels of IL-2 receptor expression and proliferation. The T0 subpopulation could also be induced to respond when cultured with anti-CD2 antibodies and phorbol myristate acetate. The results suggest that in order to respond to stimulation via the CD2 molecule, virgin T helper cells require additional signals that can be jointly provided by monocytes and IL-2. In contrast, memory T helper cells can be activated via CD2 signal transduction alone. | lld:pubmed |
| pubmed-article:2577287 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2577287 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2577287 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2577287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2577287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2577287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2577287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2577287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2577287 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:2577287 | pubmed:author | pubmed-author:ReinherzE LEL | lld:pubmed |
| pubmed-article:2577287 | pubmed:author | pubmed-author:CooperM DMD | lld:pubmed |
| pubmed-article:2577287 | pubmed:author | pubmed-author:ButlerJ LJL | lld:pubmed |
| pubmed-article:2577287 | pubmed:author | pubmed-author:ByrneJ AJA | lld:pubmed |
| pubmed-article:2577287 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2577287 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:2577287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2577287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2577287 | pubmed:pagination | 29-35 | lld:pubmed |
| pubmed-article:2577287 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:2577287 | pubmed:meshHeading | pubmed-meshheading:2577287-... | lld:pubmed |
| pubmed-article:2577287 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2577287 | pubmed:articleTitle | Virgin and memory T cells have different requirements for activation via the CD2 molecule. | lld:pubmed |
| pubmed-article:2577287 | pubmed:affiliation | Division of Development and Clinical Immunology, University of Alabama, Birmingham 35294. | lld:pubmed |
| pubmed-article:2577287 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2577287 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2577287 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2577287 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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