Linked Life Data

2575790

Source:http://linkedlifedata.com/resource/pubmed/id/2575790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1990-3-14
pubmed:abstractText
The new H2-receptor antagonist, oxmetidine was studied for its effects on the motility of the duodenum of different species. Oxmetidine did not modify basal motility of the rat and guinea pig duodenum but it reduced or abolished the contractions elicited by different spasmogenic compounds (acetylcholine, BaCl2, KCl, eledoisin). In the rabbit duodenum, oxmetidine reduced in a dose-dependent fashion the basal motility. The effect of this compound appears to be indirect on the smooth muscle and not mediated through specific receptors. Experiments performed in Ca++-free and K+-depolarizing solution suggest that oxmetidine acts through interference with the transport and/or utilization of intracellular Ca++ions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0085-5928
pubmed:author
pubmed:issnType
Print
pubmed:volume
167
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-6
pubmed:dateRevised
2008-2-13
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Action of the new H2-receptor antagonist oxmetidine on the duodenum of different species.
pubmed:affiliation
Institute of Pharmacology, University of Parma, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't