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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-12-7
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pubmed:abstractText |
Normal spleen cells cultured in high or low concentrations of interleukin (IL) 2 for 3 days contain Thy-1+ CD4- CD8+ cells that powerfully suppress primary but not ongoing or active lymphocyte responses. The precursors of these cells are Thy-1+ AGM-1- and are absent or present in greatly diminished numbers in athymic and scid mice. Suppression is neither antigen nor H-2 restricted and apparently results from reversible inactivation of resting lymphocytes. Comparable Thy-1+ CD8+ suppressor cells were also recovered from normal spleen cells cultured for 3 days with anti-CD3 antibody without added IL-2, indicating that these cells can be activated during the course of immune responses. Such cells may prevent local recruitment/activation of lymphocytes specific for new epitopes that may be expressed sequentially by proliferating tumor cells or infectious organisms.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Thy-1,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
50-63
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2572330-Animals,
pubmed-meshheading:2572330-Antigens, CD3,
pubmed-meshheading:2572330-Antigens, CD8,
pubmed-meshheading:2572330-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2572330-Antigens, Surface,
pubmed-meshheading:2572330-Antigens, Thy-1,
pubmed-meshheading:2572330-Clone Cells,
pubmed-meshheading:2572330-Cytotoxicity, Immunologic,
pubmed-meshheading:2572330-H-2 Antigens,
pubmed-meshheading:2572330-Interleukin-2,
pubmed-meshheading:2572330-Mice,
pubmed-meshheading:2572330-Mice, Inbred BALB C,
pubmed-meshheading:2572330-Mice, Inbred C3H,
pubmed-meshheading:2572330-Mice, Mutant Strains,
pubmed-meshheading:2572330-Receptors, Antigen, T-Cell,
pubmed-meshheading:2572330-Recombinant Proteins,
pubmed-meshheading:2572330-Spleen,
pubmed-meshheading:2572330-T-Lymphocytes, Regulatory
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pubmed:year |
1989
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pubmed:articleTitle |
Powerful immunosuppression mediated by interleukin 2-activated, nonantigen-specific, or H-2-restricted THY-1+ CD8+ cells.
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pubmed:affiliation |
Department of Pathology, University of Chicago, Illinois 60637.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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