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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-11-2
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pubmed:abstractText |
By using mAb and flow cytometry, a constitutive expression of the p75 IL-2R was revealed in human peripheral blood CD8+ T cells and TCR delta-1+ T cells as well as in CD16+ NK cells. Anti-p75 IL-2R mAb almost completely inhibited the induction of cytolytic activity in these T cells by brief exposure to IL-2, as estimated by anti-TCR/CD3 mAb-targeted cytotoxicity. While anti-p55 IL-2R mAb alone inhibited the response only modestly, maximal inhibition was achieved by combining both anti-p55 and anti-p75 IL-2R mAbs. These results indicate that the p75 IL-2R constitutively expressed on peripheral blood CD8+ T cells and TCR delta-1+ T cells is predominantly responsible for the direct activation of these cells by IL-2.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-2417094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-2577288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-2783438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-2784485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-2785715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-2787381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-2952709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-3040856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-3055853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-3116668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-3129919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-3160953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-3489062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-3672118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-3925553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-6156980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-6166701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571670-6413638
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1445-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2571670-Antibodies, Monoclonal,
pubmed-meshheading:2571670-Antigen-Antibody Reactions,
pubmed-meshheading:2571670-CD4-Positive T-Lymphocytes,
pubmed-meshheading:2571670-Cytotoxicity, Immunologic,
pubmed-meshheading:2571670-Humans,
pubmed-meshheading:2571670-Interleukin-2,
pubmed-meshheading:2571670-Lymphocyte Activation,
pubmed-meshheading:2571670-Molecular Weight,
pubmed-meshheading:2571670-Receptors, Interleukin-2,
pubmed-meshheading:2571670-T-Lymphocytes
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pubmed:year |
1989
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pubmed:articleTitle |
Activation of peripheral blood T cells via the p75 interleukin 2 receptor.
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pubmed:affiliation |
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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