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pubmed-article:2571667pubmed:abstractTextInsertion/deletion related polymorphisms (IDRP) involving stretches of 15-30 kb within the human TCR-beta gene complex were revealed by pulse-field gel electrophoresis. Two independent IDRP systems were detected by analysis of Sfi I- and Sal I-digested human DNA samples using probes for TCR C and V region gene segments. The allelic nature of these systems was verified in family studies, and mapping data allowed localization of one area of insertion/deletion among the V gene segments and the other near the C region genes. All but one of 50 individuals tested could be typed for the two allelic systems, and gene frequencies for the two allelic forms were 0.37/0.61 and 0.46/0.54, indicating that these polymorphisms are widespread.lld:pubmed
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pubmed-article:2571667pubmed:authorpubmed-author:KindtT JTJlld:pubmed
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pubmed-article:2571667pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:2571667pubmed:articleTitleInsertion/deletion-related polymorphisms in the human T cell receptor beta gene complex.lld:pubmed
pubmed-article:2571667pubmed:affiliationNeuroimmunology Unit, Massachusetts General Hospital, Boston 02114.lld:pubmed
pubmed-article:2571667pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2571667pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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