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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-11-2
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pubmed:abstractText |
Insertion/deletion related polymorphisms (IDRP) involving stretches of 15-30 kb within the human TCR-beta gene complex were revealed by pulse-field gel electrophoresis. Two independent IDRP systems were detected by analysis of Sfi I- and Sal I-digested human DNA samples using probes for TCR C and V region gene segments. The allelic nature of these systems was verified in family studies, and mapping data allowed localization of one area of insertion/deletion among the V gene segments and the other near the C region genes. All but one of 50 individuals tested could be typed for the two allelic systems, and gene frequencies for the two allelic forms were 0.37/0.61 and 0.46/0.54, indicating that these polymorphisms are widespread.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-2829029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-2877945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-2951480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-2965094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-2990044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-3005467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-3043226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-3297109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-3456168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-3487088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-3489234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-3491297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-3755549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-3772297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-3865189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-6202421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2571667-6336315
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1263-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2571667-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:2571667-Electrophoresis, Agar Gel,
pubmed-meshheading:2571667-Gene Frequency,
pubmed-meshheading:2571667-Humans,
pubmed-meshheading:2571667-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2571667-Receptors, Antigen, T-Cell,
pubmed-meshheading:2571667-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:2571667-Restriction Mapping
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pubmed:year |
1989
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pubmed:articleTitle |
Insertion/deletion-related polymorphisms in the human T cell receptor beta gene complex.
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pubmed:affiliation |
Neuroimmunology Unit, Massachusetts General Hospital, Boston 02114.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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