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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1989-11-21
|
| pubmed:abstractText |
The influence of training on fatty acid and glyceride synthesis by liver and adipose tissue homogenates of young and old Fischer-344 rats was examined. Four groups of rats (10 animals/group) were studied: young untrained, young trained, old untrained, and old trained. Training of each group was for 10 wk at 75% maximal O2 uptake. Young rats were killed at 6 mo of age and old rats were killed at 27 mo of age. Fatty acid synthesis was assessed by measuring the activities of acetyl-CoA carboxylase, fatty acid synthase, ATP citrate-lyase, "malic" enzyme, and glucose-6-phosphate dehydrogenase. Glyceride synthesis was evaluated by determining the rate of incorporation of [14C]glycerol 3-phosphate into lipids. In addition, lipoprotein lipase activity was measured in acetone-ether powders of adipose tissue from the four groups of rats. In liver, training had no effect on fatty acid or glyceride synthesis in either group. However, aging caused a significant decrease in the activities of four of the lipogenic enzymes but had no effect on glyceride synthesis. Training caused an increase in fatty acid synthase and glyceride synthesis in adipose tissue, and aging decreased lipoprotein lipase activity. It was concluded that training enhances the synthetic capacity of lipids by adipose tissue but that aging had a more profound effect in that the activities of the enzymes involved in these processes were lower in the old rats. Furthermore, the decreased activity of lipoprotein lipase in the older rats may explain the higher plasma triglyceride levels that were observed in these animals.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATP Citrate (pro-S)-Lyase,
http://linkedlifedata.com/resource/pubmed/chemical/Acetyl-CoA Carboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid Synthetase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosephosphate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Glycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Glycerophosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoprotein Lipase,
http://linkedlifedata.com/resource/pubmed/chemical/Malate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-glycerophosphoric acid
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
8750-7587
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
67
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1638-42
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2571607-ATP Citrate (pro-S)-Lyase,
pubmed-meshheading:2571607-Acetyl-CoA Carboxylase,
pubmed-meshheading:2571607-Adipose Tissue,
pubmed-meshheading:2571607-Aging,
pubmed-meshheading:2571607-Animals,
pubmed-meshheading:2571607-Fatty Acid Synthetase Complex,
pubmed-meshheading:2571607-Fatty Acids,
pubmed-meshheading:2571607-Glucosephosphate Dehydrogenase,
pubmed-meshheading:2571607-Glycerides,
pubmed-meshheading:2571607-Glycerophosphates,
pubmed-meshheading:2571607-Lipid Metabolism,
pubmed-meshheading:2571607-Lipoprotein Lipase,
pubmed-meshheading:2571607-Liver,
pubmed-meshheading:2571607-Malate Dehydrogenase,
pubmed-meshheading:2571607-Male,
pubmed-meshheading:2571607-Physical Conditioning, Animal,
pubmed-meshheading:2571607-Rats,
pubmed-meshheading:2571607-Rats, Inbred F344
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Influence of age and exercise training on lipid metabolism in Fischer-344 rats.
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| pubmed:affiliation |
Department of Biochemistry, School of Medicine, East Carolina University, Greenville, North Carolina 27858.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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