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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-9-8
|
| pubmed:abstractText |
A hypotensive effect of an orally-administered cyclopeptide somatostatin analog, MK-678, has been demonstrated in a hypertensive diabetic rat model. Sustained blood pressure reduction failed to occur when the drug was administered to the spontaneously hypertensive rat. The mechanism of hypotension appears independent of effects on a variety of hormones including insulin, glucagon, growth hormone, and components of the renin-angiotensin system including renin activity, plasma angiotensin converting enzyme, and aldosterone.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0024-3205
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
267-74
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2569653-Animals,
pubmed-meshheading:2569653-Blood Glucose,
pubmed-meshheading:2569653-Blood Pressure,
pubmed-meshheading:2569653-Body Weight,
pubmed-meshheading:2569653-Diabetes Mellitus, Experimental,
pubmed-meshheading:2569653-Hypertension,
pubmed-meshheading:2569653-Male,
pubmed-meshheading:2569653-Peptides, Cyclic,
pubmed-meshheading:2569653-Rats,
pubmed-meshheading:2569653-Rats, Inbred SHR,
pubmed-meshheading:2569653-Rats, Inbred Strains,
pubmed-meshheading:2569653-Reference Values,
pubmed-meshheading:2569653-Somatostatin,
pubmed-meshheading:2569653-Time Factors
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Blood pressure reduction in hypertensive-diabetic rats by the somatostatin analog MK-678.
|
| pubmed:affiliation |
Merck Sharp & Dohme Research Laboratories, Department of Biochemical Endocrinology, Rahway, NJ 07065.
|
| pubmed:publicationType |
Journal Article
|