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pubmed-article:2567440pubmed:abstractTextIn a prospective study to determine the tolerance for and safety of ivermectin therapy for onchocerciasis in a hyperendemic area in Sierra Leone, 28 (32%) of 87 patients had adverse reactions that required treatment with acetylsalicylic acid and antihistamines, but none of the observed adverse reactions were considered life-threatening. A significant relation was found between the frequency and severity of side-effects and the degree of parasite infestation, as quantified by the skin-snip counts. Free administration of ivermectin to severely infected onchocerciasis patients is not recommended without some form of medical supervision.lld:pubmed
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pubmed-article:2567440pubmed:affiliationDepartment of Ophthalmo-immunology, Netherlands Ophthalmic Research Institute, Amsterdam.lld:pubmed
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