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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1989-7-19
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pubmed:abstractText |
1. Salicylate actions on afferent nerve activity in the Xenopus lateral line and on cochlear potentials in guinea pig were investigated. 2. In the lateral line, salicylate (0.3-2.5 mM) suppressed spontaneous activity, water motion evoked excitation and responses to L-glutamate (1-2 mM) and kainate (10-20 microM). 3. In the guinea pig, salicylate (0.6-10 mM) suppressed the compound action potential (CAP) and increased N1 latency at low but not high sound intensities. 4. In the lateral line salicylate action may involve an antagonism of the hair-cell transmitter on the afferent nerve. 5. In the cochlea salicylate may suppress the active process or cochlear amplifier.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glutamates,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Ketoglutaric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Salicylates,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-ketoglutaric acid
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pubmed:status |
MEDLINE
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pubmed:issn |
0742-8413
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
73-80
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2567228-Action Potentials,
pubmed-meshheading:2567228-Animals,
pubmed-meshheading:2567228-Cochlea,
pubmed-meshheading:2567228-Female,
pubmed-meshheading:2567228-Glutamates,
pubmed-meshheading:2567228-Guinea Pigs,
pubmed-meshheading:2567228-Kainic Acid,
pubmed-meshheading:2567228-Ketoglutaric Acids,
pubmed-meshheading:2567228-Male,
pubmed-meshheading:2567228-Neurons, Afferent,
pubmed-meshheading:2567228-Salicylates,
pubmed-meshheading:2567228-Species Specificity,
pubmed-meshheading:2567228-Xenopus laevis
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pubmed:year |
1989
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pubmed:articleTitle |
Comparative actions of salicylate on the amphibian lateral line and guinea pig cochlea.
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pubmed:affiliation |
Louisiana State University Medical School, Kresge Hearing Research Laboratory, New Orleans 70012.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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