Linked Life Data

2566129

Source:http://linkedlifedata.com/resource/pubmed/id/2566129

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-6-12
pubmed:abstractText
The present study was performed to gain more information on the nature of the opioid peptide(s) involved in the mechanism of action of alpha-methyldopa. Conscious, normotensive Wistar rats were used and all treatments were given intracisternally. For blood pressure and heart rate, pretreatment with a midportion beta-endorphin antiserum resulted in a parallel shift to the right of the dose-response curve for alpha-methyldopa. In addition, when rats were pretreated with various dilutions of this antiserum and treated with a constant dose of alpha-methyldopa, the antiserum dose-dependently inhibited alpha-methyldopa-induced hypotension and bradycardia. Using antisera specifically recognizing the C-terminus of beta-, gamma- and alpha-endorphin, respectively, revealed that only the beta-endorphin antiserum inhibited the decrease in blood pressure seen after administration of alpha-methyldopa. An antiserum against [Met5]enkephalin did not influence the cardiovascular responses following alpha-methyldopa. On the other hand, a dynorphin(1-13) antiserum also inhibited in a dose-dependent manner the hypotension induced by alpha-methyldopa. When administered 3 h after the injection of alpha-methyldopa, the beta-endorphin and dynorphin(1-13) antisera failed to reverse the hypotension induced by alpha-methyldopa. The results favor a role for beta-endorphin(1-31) and dynorphin(1-13) in the hypotension centrally mediated by alpha-methyldopa.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Possible involvement of beta endorphin(1-31) and dynorphin(1-13) in the central hypotensive mechanism of action of alpha methyldopa.
pubmed:affiliation
Rudolf Magnus Institute for Pharmacology, Medical Faculty, State University of Utrecht, The Netherlands.
pubmed:publicationType
Journal Article