Linked Life Data

2565927

Source:http://linkedlifedata.com/resource/pubmed/id/2565927

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1989-6-19
pubmed:databankReference
pubmed:abstractText
The gene encoding human complement receptor 2 (CR2) lies within a cluster of genes on human chromosome 1. Polymorphisms have been described for several of these genes or gene products. To examine any possible polymorphisms in the CR2 gene product we have analyzed the CR2 transcriptional products for variations via alternative exon usage and for the presence of different CR2 alleles within the human population. This analysis has suggested that an exon encoding a 60 amino acid short consensus repeat can be alternatively spliced. Evidence for two transcriptional products has been found in a variety of transformed human B cells and two human tonsils. Interestingly the ratio of the two forms of mRNA, that which includes the alternative exon and that which does not, is not constant when examining the RNA from these sources. In addition to the variation introduced by the alternatively spliced product, there appears to exist in the human population at least three different alleles for CR2. These alleles have been defined by multiple nucleotide changes which are not silent but which alter the amino acid encoded at that site. However, we have not identified allelic variants of CR2 which would produce a product varying in the number of long homologous repeats, as has been identified for the various alleles of the closely related protein, human complement receptor 1.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
142
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3668-75
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Variability of CR2 gene products is due to alternative exon usage and different CR2 alleles.
pubmed:affiliation
Department of Medicine, Harvard Medical School, Boston, MA 02115.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't