2564007

Source:http://linkedlifedata.com/resource/pubmed/id/2564007

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0019069, umls-concept:C0030705, umls-concept:C0041290, umls-concept:C1692321, umls-concept:C2603343
pubmed:issue	2
pubmed:dateCreated	1989-4-20
pubmed:abstractText	The number of microanatomical location of CD4 and CD8 lymphocytes, of cells bearing receptors for I12 and transferrin, and of monocyte/macrophages in the dermis at the site of a tuberculin test were measured in 13 patients with haemophilia (10 seronegative and three seropositive for human immunodeficiency virus (HIV]. The overall density of lymphocytes in the perivascular and diffuse parts of the infiltrate was similar to that reported in other groups of subjects without evidence of immunosuppression. The CD4:CD8 ratio of the infiltrating lymphocytes throughout the section showed an inverse relation with clotting factor consumption. There was no significant change in the CD4:CD8 ratio in the diffuse infiltrate at various levels into the dermis in tuberculin reactions in patients with haemophilia, unlike healthy controls and other groups with no evidence of immunosuppression, who have previously been shown to have increasing CD4:CD8 ratio with increasing depth into the dermis. The number of cells bearing receptors for I12 and transferrin and of monocyte/macrophages was related to total lymphocyte density in the infiltrate. There was no evidence of serious impairment of the cell mediated response to a long term recall antigen, but the relatively low preponderance of CD4 lymphocytes in the diffuse infiltrate, particularly in the deeper dermis, may be the earliest indicator of impending immunosuppression.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-2862416, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-3094762, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-3105685, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-3461740, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-3493262, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-3539419, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-3665186, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-6134028, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-6138562, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-6150048, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-6151053, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-6226334, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-6360446, http://linkedlifedata.com/resource/pubmed/commentcorrection/2564007-6606885
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0376601
pubmed:citationSubset	AIM
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0021-9746
pubmed:author	pubmed-author:BeckJ SJS, pubmed-author:ForbesC DCD, pubmed-author:GibbsJ HJH, pubmed-author:GracieAA, pubmed-author:LoweG DGD, pubmed-author:MadhokRR, pubmed-author:Noe'CC, pubmed-author:PottsR CRC
pubmed:issnType	Print
pubmed:volume	42
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	184-7
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:2564007-CD4-Positive T-Lymphocytes, pubmed-meshheading:2564007-Hemophilia A, pubmed-meshheading:2564007-Humans, pubmed-meshheading:2564007-Leukocyte Count, pubmed-meshheading:2564007-T-Lymphocytes, pubmed-meshheading:2564007-Tuberculin Test
pubmed:year	1989
pubmed:articleTitle	Histometric studies on cellular infiltrates of tuberculin tests in patients with haemophilia.
pubmed:affiliation	Department of Pathology, University of Dundee, University of Glasgow, Scotland.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't