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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1989-3-23
|
| pubmed:abstractText |
A detailed genetic and physical map of human complement factor I (IF) using somatic cell hybrids, in situ hybridization, and genetic linkage is reported. The gene has been localized to band 4q25. The order GC-INP10-ADH3-EGF-IF-IL2-MNS is proposed for genes on 4q on the basis of genetic and physical mapping techniques. A BclI polymorphism found with the IF probe demonstrated a maternal origin for a de novo deletion of chromosome 4 that was used in physically mapping the gene. The genetic and physical distances around band 4q24 suggest that 1 cM is approximately 1.2 million bp of DNA. This work provides a useful addition to the map of 4q.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0888-7543
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
82-6
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:2563353-Chromosome Mapping,
pubmed-meshheading:2563353-Chromosomes, Human, Pair 4,
pubmed-meshheading:2563353-Complement Factor I,
pubmed-meshheading:2563353-Genetic Linkage,
pubmed-meshheading:2563353-Humans,
pubmed-meshheading:2563353-Hybrid Cells,
pubmed-meshheading:2563353-Nucleic Acid Hybridization,
pubmed-meshheading:2563353-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:2563353-Serine Endopeptidases
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Mapping of the human complement factor I gene to 4q25.
|
| pubmed:affiliation |
Department of Pediatrics, University of Iowa, Iowa City 52242.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|