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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-3-2
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pubmed:abstractText |
In astrocytes grown in primary cultures from cerebral cortex of neonatal rats, alpha 1-adrenoceptors regulate the active uptake of glutamate followed by an activation of glutamic oxaloacetate transaminase (GOT; EC 2.6.1.1.) and a slight activation of glutamine synthetase (GS; EC 6.3.1.2.) activity. The beta-adrenoceptors regulate the active uptake of GABA, and this is followed by an activation of gamma-aminobutyric acid alpha-ketoglutarate transaminase (GABA-T; EC 2.6.1.19.). The data suggest that astrocyte adrenoceptors may modulate neurotransmitter induced neuronal excitability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-34
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2563301-4-Aminobutyrate Transaminase,
pubmed-meshheading:2563301-Animals,
pubmed-meshheading:2563301-Aspartate Aminotransferases,
pubmed-meshheading:2563301-Astrocytes,
pubmed-meshheading:2563301-Biological Transport, Active,
pubmed-meshheading:2563301-Cells, Cultured,
pubmed-meshheading:2563301-Cerebral Cortex,
pubmed-meshheading:2563301-Glutamate-Ammonia Ligase,
pubmed-meshheading:2563301-Glutamates,
pubmed-meshheading:2563301-Glutamic Acid,
pubmed-meshheading:2563301-Rats,
pubmed-meshheading:2563301-Rats, Inbred Strains,
pubmed-meshheading:2563301-Receptors, Adrenergic,
pubmed-meshheading:2563301-gamma-Aminobutyric Acid
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pubmed:year |
1989
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pubmed:articleTitle |
Regulation of glutamate and GABA transport by adrenoceptors in primary astroglial cell cultures.
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pubmed:affiliation |
Institute of Neurobiology, University of Göteborg, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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