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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1990-4-26
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pubmed:abstractText |
The properties of the Ca2+ channels mediating transmitter release in vertebrate neurons have not yet been described with voltage-clamp techniques. Several types of voltage-dependent Ca2+ channels are known to exist on neuronal somata, but the small size and inaccessibility of most vertebrate nerve endings have precluded direct characterization of the presynaptic channels. However, large nerve endings, which release the peptides oxytocin and vasopressin in a Ca2(+)-dependent manner, can be dissociated from the rat neurohypophysis. Using both single-channel and whole-cell patch-clamp techniques, we have characterized two types of Ca2+ channels that coexist in these terminals. One is a large-conductance, high-threshold, dihydropyridine-sensitive channel that contributes a slowly inactivating current. The second is a smaller conductance channel, which is also activated at high thresholds, but underlies a rapidly inactivating, dihydropyridine-insensitive current. Both types of Ca2+ channels may participate in the peptide release process.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,4-dihydropyridine,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydropyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Oxytocin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasopressins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0896-6273
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1419-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2560641-Action Potentials,
pubmed-meshheading:2560641-Animals,
pubmed-meshheading:2560641-Calcium,
pubmed-meshheading:2560641-Calcium Channels,
pubmed-meshheading:2560641-Dihydropyridines,
pubmed-meshheading:2560641-Ion Channel Gating,
pubmed-meshheading:2560641-Male,
pubmed-meshheading:2560641-Nerve Endings,
pubmed-meshheading:2560641-Oxytocin,
pubmed-meshheading:2560641-Pituitary Gland, Posterior,
pubmed-meshheading:2560641-Rats,
pubmed-meshheading:2560641-Vasopressins
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pubmed:year |
1989
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pubmed:articleTitle |
Two types of calcium channels coexist in peptide-releasing vertebrate nerve terminals.
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pubmed:affiliation |
Neurobiology Group, Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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