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rdf:type |
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lifeskim:mentions |
umls-concept:C0014939,
umls-concept:C0017355,
umls-concept:C0019627,
umls-concept:C0034987,
umls-concept:C0205164,
umls-concept:C0527031,
umls-concept:C0600508,
umls-concept:C0680022,
umls-concept:C0887829,
umls-concept:C1145667,
umls-concept:C1456393
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pubmed:issue |
21
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pubmed:dateCreated |
1989-12-8
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pubmed:databankReference |
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pubmed:abstractText |
Transcription of major histocompatibility complex (MHC) class I genes is regulated by the conserved MHC class I regulatory element (CRE). The CRE has two factor-binding sites, region I and region II, both of which elicit enhancer function. By screening a mouse lambda gt 11 library with the CRE as a probe, we isolated a cDNA clone that encodes a protein capable of binding to region II of the CRE. This protein, H-2RIIBP (H-2 region II binding protein), bound to the native region II sequence, but not to other MHC cis-acting sequences or to mutant region II sequences, similar to the naturally occurring region II factor in mouse cells. The deduced amino acid sequence of H-2RIIBP revealed two putative zinc fingers homologous to the DNA-binding domain of steroid/thyroid hormone receptors. Although sequence similarity in other regions was minimal, H-2RIIBP has apparent modular domains characteristic of the nuclear hormone receptors. Further analyses showed that both H-2RIIBP and the natural region II factor bind to the estrogen response element (ERE) of the vitellogenin A2 gene. The ERE is composed of a palindrome, and half of this palindrome resembles the region II binding site of the MHC CRE. These results indicate that H-2RIIBP (i) is a member of the superfamily of nuclear hormone receptors and (ii) may regulate not only MHC class I genes but also genes containing the ERE and related sequences. Sequences homologous to the H-2RIIBP gene are widely conserved in the animal kingdom. H-2RIIBP mRNA is expressed in many mouse tissues, in agreement with the distribution of the natural region II factor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-2644044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-2825025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-2848202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-2849110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-2850264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-2879243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-2881624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-2904128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-2926327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-2964277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3034432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3043231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3061875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3063603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3125612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3167974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3167984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3186734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3192155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3208750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3283939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3313046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3322806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3396073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3463433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3467324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3480798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3501825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3510743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3538016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3561391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3780669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-3816760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2554307-6328658
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8289-93
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2554307-Amino Acid Sequence,
pubmed-meshheading:2554307-Animals,
pubmed-meshheading:2554307-Base Sequence,
pubmed-meshheading:2554307-Cell Nucleus,
pubmed-meshheading:2554307-Cloning, Molecular,
pubmed-meshheading:2554307-DNA-Binding Proteins,
pubmed-meshheading:2554307-Gene Expression Regulation,
pubmed-meshheading:2554307-Gene Library,
pubmed-meshheading:2554307-Genes,
pubmed-meshheading:2554307-Genes, MHC Class I,
pubmed-meshheading:2554307-Genes, Regulator,
pubmed-meshheading:2554307-Liver,
pubmed-meshheading:2554307-Mice,
pubmed-meshheading:2554307-Molecular Sequence Data,
pubmed-meshheading:2554307-Multigene Family,
pubmed-meshheading:2554307-Oligonucleotide Probes,
pubmed-meshheading:2554307-Receptors, Cell Surface,
pubmed-meshheading:2554307-Transcription, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element.
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pubmed:affiliation |
Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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