| pubmed-article:2553266 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2553266 | lifeskim:mentions | umls-concept:C0184512 | lld:lifeskim |
| pubmed-article:2553266 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:2553266 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:2553266 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:2553266 | lifeskim:mentions | umls-concept:C0965144 | lld:lifeskim |
| pubmed-article:2553266 | lifeskim:mentions | umls-concept:C1100939 | lld:lifeskim |
| pubmed-article:2553266 | lifeskim:mentions | umls-concept:C1506764 | lld:lifeskim |
| pubmed-article:2553266 | lifeskim:mentions | umls-concept:C1566354 | lld:lifeskim |
| pubmed-article:2553266 | lifeskim:mentions | umls-concept:C1723137 | lld:lifeskim |
| pubmed-article:2553266 | lifeskim:mentions | umls-concept:C1957815 | lld:lifeskim |
| pubmed-article:2553266 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2553266 | pubmed:dateCreated | 1989-12-4 | lld:pubmed |
| pubmed-article:2553266 | pubmed:abstractText | We studied regulation of human immunodeficiency virus-1 (HIV-1) transcription by Tat and, for comparative purposes, by the adenovirus E1A protein. These two trans-activators exerted different effects. Two classes of HIV-1-promoted cytoplasmic RNA were detected, one class corresponding to full-length transcripts and the other to transcripts ending 55 and 59 nucleotides from the transcription start. Tat increased the level of the full-length class only, whereas E1A increased the levels of both classes of RNA. We also measured the effects of Tat and E1A on RNA synthesis rates. Without trans-activators, HIV-1-directed transcription was relatively weak and exhibited a marked polarity. Both Tat and E1A dramatically increased promoter-proximal transcription, while only Tat suppressed transcriptional polarity. Mutations in the TAR element did not influence basal transcription rates or the response to E1A, but eliminated trans-activation by Tat. We propose that Tat acts through TAR to increase initiation complex formation on the HIV-1 promoter and to stabilize complexes during elongation. | lld:pubmed |
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| pubmed-article:2553266 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2553266 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2553266 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2553266 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2553266 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2553266 | pubmed:author | pubmed-author:MathewsM BMB | lld:pubmed |
| pubmed-article:2553266 | pubmed:author | pubmed-author:LaspiaM FMF | lld:pubmed |
| pubmed-article:2553266 | pubmed:author | pubmed-author:RiceA PAP | lld:pubmed |
| pubmed-article:2553266 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2553266 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:2553266 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:2553266 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2553266 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2553266 | pubmed:pagination | 283-92 | lld:pubmed |
| pubmed-article:2553266 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:2553266 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2553266 | pubmed:articleTitle | HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation. | lld:pubmed |
| pubmed-article:2553266 | pubmed:affiliation | Cold Spring Harbor Laboratory, New York 11724. | lld:pubmed |
| pubmed-article:2553266 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2553266 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2553266 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2553266 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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