Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-10-28
pubmed:abstractText
Epstein-Barr virus (EBV) is associated with lymphomas and lymphoproliferative diseases that occur mainly in immunocompromised patients, but the role EBV plays in their pathogenesis is unclear. The evidence linking EBV etiologically to these disorders includes the presence of EBV DNA and nuclear antigens in the lesions and serologic evidence that some patients with these lesions are experiencing primary or reactivated EBV infections. These syndromes may represent proliferation of cells latently infected with EBV, but the possibility of viral replication has not been rigorously studied. DNA extracted from biopsies of 35 lymphoproliferative diseases was probed with regions of the EBV genome capable of distinguishing circular, episomal DNA found in latency from linear, replicating EBV DNA. All samples contained restriction fragments characteristic of fused termini, indicative of circular, latent genomes. Thirteen samples contained additional restriction fragments diagnostic of linear EBV DNA. Therefore, replicating EBV DNA is found in approximately 40% of EBV-associated lymphoproliferative disorders.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
160
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
589-98
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:2551973-Acyclovir, pubmed-meshheading:2551973-Adolescent, pubmed-meshheading:2551973-Adult, pubmed-meshheading:2551973-Blotting, Southern, pubmed-meshheading:2551973-Burkitt Lymphoma, pubmed-meshheading:2551973-Cell Line, pubmed-meshheading:2551973-Child, pubmed-meshheading:2551973-Child, Preschool, pubmed-meshheading:2551973-DNA, Viral, pubmed-meshheading:2551973-DNA Probes, pubmed-meshheading:2551973-DNA Replication, pubmed-meshheading:2551973-Deoxyribonuclease BamHI, pubmed-meshheading:2551973-Female, pubmed-meshheading:2551973-Herpesvirus 4, Human, pubmed-meshheading:2551973-Humans, pubmed-meshheading:2551973-Immune Tolerance, pubmed-meshheading:2551973-Lymphoma, pubmed-meshheading:2551973-Lymphoproliferative Disorders, pubmed-meshheading:2551973-Male, pubmed-meshheading:2551973-Middle Aged, pubmed-meshheading:2551973-Nucleic Acid Hybridization, pubmed-meshheading:2551973-Restriction Mapping, pubmed-meshheading:2551973-Tumor Cells, Cultured, pubmed-meshheading:2551973-Virus Replication
pubmed:year
1989
pubmed:articleTitle
Latent and replicating forms of Epstein-Barr virus DNA in lymphomas and lymphoproliferative diseases.
pubmed:affiliation
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't