Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1989-9-11
pubmed:abstractText
A transcriptional trans-acting factor p40tax of human T-cell leukemia virus type I (HTLV-I) functions as an inducer for expression of HTLV-I provirus via activation of the enhancer in the long terminal repeat of HTLV-I. In addition to p40tax and a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, we report here that forskolin, an activator of adenyl cyclase, also induces function of the HTLV-I enhancer. Experiments with mutants of the HTLV-I enhancer revealed that TPA-induced activation was not mediated by solely a 21-base-pair (bp) sequence that is repeated three times in the enhancer, whereas the 21-bp enhancer element can act as a sufficient cis-acting sequence for activation by both p40tax and forskolin. In addition, we found that nuclear factor(s) like the cyclic AMP-responsive element (CRE) binding factor could bind to the HTLV-I 21-bp enhancer element. However, a difference was found in sequences required for activation by p40tax and forskolin. A CRE related sequence present in the 21-bp enhancer element was enough for forskolin-induced activation. On the other hand, p40tax required a much longer sequence that is overlapping but not identical to the CRE related sequence, suggesting that the forskolin-induced cyclic AMP pathway may be partly involved in, but not sufficient for p40tax-mediating trans-activation of the HTLV-I enhancer.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-1087116, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-208147, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2521922, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2784206, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2822488, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2825351, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2826822, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2834649, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2835770, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2838755, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2840644, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2843294, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2847164, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2871307, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2875459, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2885756, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2900470, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2960975, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2974179, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2990028, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2991599, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2992082, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-2995982, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3009027, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3011413, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3015903, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3018737, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3020428, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3022280, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3026643, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3030566, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3031512, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3034589, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3037548, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3091258, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3263510, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-3287617, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-6177038, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-6320367, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-6413574, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-6951204, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-6960240, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-6979048, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-6981536, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-7031654, http://linkedlifedata.com/resource/pubmed/commentcorrection/2548156-7066985
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0305-1048
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5207-21
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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