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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1989-7-31
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pubmed:abstractText |
The presence of receptors for epidermal growth factor (EGF-R), the percentage of cells in S-phase and DNA-ploidy measured by flow-cytometry are new prognostic factors in breast cancer. In order to investigate the relationship between EGF-R, S-Phase/DNA-ploidy and clinical data, we measured these parameters in 68 tumors from patients with operable breast cancer. 11 Patients had positive EGF-R's (specific binding greater than 10 fmol/mg membrane-protein) and 37 patients had a positive S-Phase (more than 5% of cells in S-Phase). 10 of 44 carcinomas of ductal type were EGF-R positive, while only 1 of 18 lobular-type tumor displayed positive EGF-R's. We found significant inverse correlations between EGF-R's and estrogen receptors (p less than 0.00001) and between EGF-R's and age (p less than 0.0001): EGF-R positive tumors were found more often in young patients and in patients with estrogen-receptor-negative tumors. The EGF-R's and flow-cytometric data did not correlate with tumor size and/or nodal status. There was no correlation between EGF-R and S-Phase/DNA-ploidy in the breast cancer specimens suggesting that these two prognostic parameters are independent from each other.
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pubmed:language |
ger
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0016-5751
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2544476-Biopsy,
pubmed-meshheading:2544476-Breast,
pubmed-meshheading:2544476-Breast Neoplasms,
pubmed-meshheading:2544476-Carcinoma,
pubmed-meshheading:2544476-Carcinoma, Intraductal, Noninfiltrating,
pubmed-meshheading:2544476-DNA, Neoplasm,
pubmed-meshheading:2544476-Female,
pubmed-meshheading:2544476-Flow Cytometry,
pubmed-meshheading:2544476-Humans,
pubmed-meshheading:2544476-Interphase,
pubmed-meshheading:2544476-Lymph Nodes,
pubmed-meshheading:2544476-Lymphatic Metastasis,
pubmed-meshheading:2544476-Middle Aged,
pubmed-meshheading:2544476-Ploidies,
pubmed-meshheading:2544476-Prognosis,
pubmed-meshheading:2544476-Receptor, Epidermal Growth Factor,
pubmed-meshheading:2544476-Receptors, Estrogen,
pubmed-meshheading:2544476-Receptors, Progesterone
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pubmed:year |
1989
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pubmed:articleTitle |
[Epithelial growth factor receptors (EGF-R) and DNA flow cytometry in addition to lymph node and hormone receptor status as prognostic factors in primary breast cancer].
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pubmed:affiliation |
Universitätsfrauenklinik Heidelberg.
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pubmed:publicationType |
Journal Article,
English Abstract
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