Linked Life Data

2542386

Source:http://linkedlifedata.com/resource/pubmed/id/2542386

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-7-5
pubmed:abstractText
The 67N strain of haemagglutinating encephalomyelitis virus (HEV) was inoculated orally or nasally into ten 3-day-old gnotobiotic piglets. Tonsillar changes characterized by epithelial degeneration and lymphatic cell infiltration occurred in the crypt from post-inoculation days (PID) 5 to 7, and HEV was isolated from the tonsil on PID 3 and 5. Ultrastructurally, many HEV particles were found in the cisternae, cytoplasmic vesicules and extracellular spaces of crypt epithelium. Immunohistologically, many HEV particles were observed in the crypt epithelial cells in the early stage of infection. Thereafter, a large number of immunoglobulin (IgG, IgM and IgA)-containing cells were observed in the tonsil. The appearance of IgM-containing cells was coincident with the detection of neutralizing antibody in the serum. These findings suggest that HEV replication in the crypt epithelium stimulates the proliferative response of immunoglobulin (IgG, IgM and IgA)-producing cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9975
pubmed:author
pubmed:issnType
Print
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
305-12
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Immunopathological and ultrastructural studies on the tonsil of gnotobiotic pigs infected with strain 67N of haemagglutinating encephalomyelitis virus.
pubmed:affiliation
Systematic Diagnosis Research Division, National Institute of Animal Health, Ibaraki, Japan.
pubmed:publicationType
Journal Article