Linked Life Data

2541389

Source:http://linkedlifedata.com/resource/pubmed/id/2541389

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-6-12
pubmed:abstractText
A rearranged bovine papillomavirus type 4 DNA fragment, present in a line of transformed C127 cells, was molecularly cloned into lambda GT 10. The rearranged viral fragment was found to consist of two separate sequences of 3.8 kb each. Clone A comprised 3.3 kb of host DNA linked to 0.5 kb of BPV-4 DNA. Clone B consisted of 2.2 kb of host DNA linked to 1.5 kb of BPV-4 DNA. The AB locus was found to be amplified and rearranged in a number of different BPV-4 transformed C127 cell lines, irrespective of the presence of viral DNA. The rearranged amplified locus was transferred and maintained in second and third round transformants. We propose that the altered AB locus is involved in the maintenance of the transformed phenotype in the absence of the BPV-4 DNA, and may act as an activated oncogene.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Amplification of specific DNA sequences in C127 mouse cells transformed by bovine papillomavirus type 4.
pubmed:affiliation
Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't