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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-5-30
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pubmed:abstractText |
Several experiments were conducted to examine the effects of intracranial injection of opioid peptides and antagonists on learning and memory in the chick. Pretraining injection of [leu5]enkephalin and the selective delta receptor agonist [D-Pen2,L-Pen5]enkephalin (DPLPE) into the intermediate medial hyperstriatum ventrale (IMHV) produced impairment. ICI 174,864, a delta-selective antagonist, reversed the impairment produced by either [leu5]enkephalin or DPLE, results indicating that delta receptors may play a role in learning in the chick and suggesting that the impairment produced by [leu5]enkephalin is mediated through delta opioid receptors. beta-endorphin produced a naloxone-reversible impairment in performance, which suggests that this impairment is mediated by opioid receptors. Bilateral injection of beta-endorphin into the IMHV produced impairment, as did unilateral injection into the right, but not left, IMHV. Only bilateral injections into IMHV of [leu5]enkephalin were effective. These results suggest that the effects of beta-endorphin are centrally mediated whereas the effects of [leu5]enkephalin may be localized to other brain regions or are peripherally mediated. These initial results suggest that opioids are associated with learning and memory in the chick.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Endorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, D-Penicillamine (2,5)-,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Leucine,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalins,
http://linkedlifedata.com/resource/pubmed/chemical/N,N-diallyl-tyrosyl-alpha-aminoisobu...,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, delta,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Endorphin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0735-7044
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
429-37
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2539840-Animals,
pubmed-meshheading:2539840-Attention,
pubmed-meshheading:2539840-Brain Mapping,
pubmed-meshheading:2539840-Chickens,
pubmed-meshheading:2539840-Discrimination Learning,
pubmed-meshheading:2539840-Dominance, Cerebral,
pubmed-meshheading:2539840-Dose-Response Relationship, Drug,
pubmed-meshheading:2539840-Endorphins,
pubmed-meshheading:2539840-Enkephalin, D-Penicillamine (2,5)-,
pubmed-meshheading:2539840-Enkephalin, Leucine,
pubmed-meshheading:2539840-Enkephalins,
pubmed-meshheading:2539840-Male,
pubmed-meshheading:2539840-Memory,
pubmed-meshheading:2539840-Mental Recall,
pubmed-meshheading:2539840-Naloxone,
pubmed-meshheading:2539840-Receptors, Opioid,
pubmed-meshheading:2539840-Receptors, Opioid, delta,
pubmed-meshheading:2539840-Visual Cortex,
pubmed-meshheading:2539840-beta-Endorphin
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pubmed:year |
1989
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pubmed:articleTitle |
Influence of opioid peptides on learning and memory processes in the chick.
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pubmed:affiliation |
Department of Psychology, University of California, Berkely 94720.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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