Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1989-5-10
|
| pubmed:abstractText |
Neuron-specific enolase (NSE) was purified from human brain to a specific activity of 91 U/mg with no demonstrable impurities. The enzyme has a molecular weight of 96,000, consists of two subunits of 47,000, and has an isoelectric point at pH 4.5. A radioimmunoassay based on antibody raised in sheep was established. The assay has a sensitivity of 2 micrograms/l, and an interassay coefficient of variation of 6.4% at 10 micrograms/l. The reference limit was defined as 10 micrograms/l, as found in sera from a population of 389 persons. Of 50 untreated patients with small cell lung cancer (SCLC), 70% had NSE levels above 10 micrograms/l. None of 170 patients with non-SCLC neoplasms had elevated enzyme levels.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1010-4283
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
23-30
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2538916-Adult,
pubmed-meshheading:2538916-Aged,
pubmed-meshheading:2538916-Blood Platelets,
pubmed-meshheading:2538916-Brain,
pubmed-meshheading:2538916-Carcinoma, Small Cell,
pubmed-meshheading:2538916-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:2538916-Erythrocytes,
pubmed-meshheading:2538916-Female,
pubmed-meshheading:2538916-Humans,
pubmed-meshheading:2538916-Immune Sera,
pubmed-meshheading:2538916-Leukocytes,
pubmed-meshheading:2538916-Lung Neoplasms,
pubmed-meshheading:2538916-Male,
pubmed-meshheading:2538916-Middle Aged,
pubmed-meshheading:2538916-Phosphopyruvate Hydratase,
pubmed-meshheading:2538916-Radioimmunoassay,
pubmed-meshheading:2538916-Reference Values,
pubmed-meshheading:2538916-Tumor Markers, Biological
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Establishment and evaluation of a radioimmunoassay for neuron-specific enolase. A marker for small cell lung cancer.
|
| pubmed:affiliation |
Central Laboratory, Norwegian Radium Hospital, Oslo, Norway.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|