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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1989-3-8
|
pubmed:abstractText |
(-)-N-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one (2) was synthesized with 4,14-dimethoxy-N-methylmorphinan-6-one (1) as starting material. In vivo and in vitro experiments show 2 (cyprodime) to be a pure opioid receptor antagonist. Some of these tests (opioid receptor binding assays, guinea pig ileal longitudinal muscle preparation, rat and mouse vas deferens preparation, acetic acid writhing antagonism test) indicate that 2 is a selective mu opioid receptor antagonist.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0022-2623
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
32
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
418-21
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pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2536439-Animals,
pubmed-meshheading:2536439-Guinea Pigs,
pubmed-meshheading:2536439-Male,
pubmed-meshheading:2536439-Mice,
pubmed-meshheading:2536439-Morphinans,
pubmed-meshheading:2536439-Narcotic Antagonists,
pubmed-meshheading:2536439-Rats,
pubmed-meshheading:2536439-Receptors, Opioid,
pubmed-meshheading:2536439-Receptors, Opioid, mu
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pubmed:year |
1989
|
pubmed:articleTitle |
Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.
|
pubmed:affiliation |
Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck, Austria.
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pubmed:publicationType |
Journal Article,
In Vitro
|