Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4937
pubmed:dateCreated
1990-1-25
pubmed:abstractText
Granulocyte and natural killer (NK) cell Fc receptors for immunoglobulin G (CD16) differ in only a few amino acids, yet have phosphatidylinositol glycan (PIG) or polypeptide membrane anchors, respectively. Mutagenesis shows that anchoring is regulated by a serine residue near the PIG anchor attachment site in the extracellular domain. The NK cell isoform was not expressed on the surface of COS cells unless cotransfected with a subunit that was expressed in NK cells and that was identical to the gamma subunit of the high affinity IgE Fc receptor (Fc epsilon RI). However, the CD16 sequence and not expression of the gamma subunit is dominant in regulating PIG reanchoring.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
246
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1608-11
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed-meshheading:2531918-Animals, pubmed-meshheading:2531918-Antigens, CD, pubmed-meshheading:2531918-Antigens, Differentiation, pubmed-meshheading:2531918-Cell Line, pubmed-meshheading:2531918-Cell Membrane, pubmed-meshheading:2531918-Flow Cytometry, pubmed-meshheading:2531918-Gene Expression Regulation, pubmed-meshheading:2531918-Genes, Immunoglobulin, pubmed-meshheading:2531918-Granulocytes, pubmed-meshheading:2531918-Humans, pubmed-meshheading:2531918-Immunoglobulin G, pubmed-meshheading:2531918-Killer Cells, Natural, pubmed-meshheading:2531918-L Cells (Cell Line), pubmed-meshheading:2531918-Mice, pubmed-meshheading:2531918-Mutation, pubmed-meshheading:2531918-RNA, Messenger, pubmed-meshheading:2531918-Receptors, Fc, pubmed-meshheading:2531918-Receptors, IgG, pubmed-meshheading:2531918-Transcription, Genetic, pubmed-meshheading:2531918-Transfection
pubmed:year
1989
pubmed:articleTitle
Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16).
pubmed:affiliation
Department of Pathology, Harvard Medical School, Boston, MA 02115.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't