Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1990-1-24
pubmed:abstractText
Cloned human dopamine D2 receptor cDNA was isolated from a pituitary cDNA library and found to encode an additional 29 amino acid residues in the predicted intracellular domain between transmembrane regions 5 and 6 relative to a previously described rat brain D2 receptor. Results from polymerase chain reactions as well as in situ hybridization revealed that mRNA encoding both receptor forms is present in pituitary and brain of both rat and man. The larger form was predominant in these tissues and, as shown in the rat, expressed by dopaminergic and dopaminoceptive neurons. Analysis of the human gene showed that the additional peptide sequence is encoded by a separate exon. Hence, the two receptor forms are generated by differential splicing possibly to permit coupling to different G proteins. Both receptors expressed in cultured mammalian cells bind [3H]spiperone with high affinity and inhibit adenylyl cyclase, as expected of the D2 receptor subtype.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-215920, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2451115, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2502842, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2523750, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2548325, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2552081, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2560388, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2570461, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2571500, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2744760, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2759239, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2836950, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2840250, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2854054, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2867474, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2974511, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-2985470, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3001650, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3005316, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3018746, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3038163, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3104325, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3197827, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3431465, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3443095, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-358777, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-36204, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3754925, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3792556, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-3996185, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-43260, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-5482108, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-6090951, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-6117090, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-625348, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-6259625, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-6357679, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-723958, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-7263835, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-728996, http://linkedlifedata.com/resource/pubmed/commentcorrection/2531656-945467
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4025-34
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:2531656-Humans, pubmed-meshheading:2531656-Pituitary Gland, pubmed-meshheading:2531656-Mutation, pubmed-meshheading:2531656-DNA, pubmed-meshheading:2531656-Autoradiography, pubmed-meshheading:2531656-Genes, pubmed-meshheading:2531656-Sulfur Radioisotopes, pubmed-meshheading:2531656-Base Sequence, pubmed-meshheading:2531656-RNA, Messenger, pubmed-meshheading:2531656-Amino Acid Sequence, pubmed-meshheading:2531656-Molecular Sequence Data, pubmed-meshheading:2531656-Nucleic Acid Hybridization, pubmed-meshheading:2531656-Cloning, Molecular, pubmed-meshheading:2531656-Plasmids, pubmed-meshheading:2531656-Restriction Mapping, pubmed-meshheading:2531656-Receptors, Dopamine, pubmed-meshheading:2531656-Genetic Vectors, pubmed-meshheading:2531656-Exons, pubmed-meshheading:2531656-RNA Splicing, pubmed-meshheading:2531656-Receptors, Dopamine D2, pubmed-meshheading:2531656-Oligonucleotide Probes, pubmed-meshheading:2531656-Polymerase Chain Reaction
More...