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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024518,
umls-concept:C0086860,
umls-concept:C0185117,
umls-concept:C0282641,
umls-concept:C0332120,
umls-concept:C0456387,
umls-concept:C0851285,
umls-concept:C0884118,
umls-concept:C1158770,
umls-concept:C1709313,
umls-concept:C2587213,
umls-concept:C2911684
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pubmed:issue |
9
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pubmed:dateCreated |
1989-9-12
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pubmed:abstractText |
The E1 region of human adenovirus type 12 (Ad12 E1) represses the expression of major histocompatibility complex (MHC) class I genes in transformed primary rodent cells. Conflicting results have been reported as to whether this E1A-mediated repression occurs at a transcriptional or a posttranscriptional level. In the present study, we show that in Ad12 E1-transformed primary baby mouse kidney cells from transgenic mice harboring the human growth hormone gene under control of an H-2K promoter both the expression of the endogenous MHC class I genes and the expression of the transgene are repressed. This experiment, as well as nuclear run-on analyses performed with single-stranded probes, revealed that Ad12 E1A inhibits MHC class I gene expression by repressing its promoter.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2484015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2521677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2820718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2830991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2942760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2944600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2951598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2957064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2962857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2965790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2967913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2968158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2968712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2982503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-2999984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3011403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3019667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3025599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3028247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3096575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3125612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3205738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3288540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3402430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3501825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3510743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3520340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3554244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3561391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-3823900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-6095113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-6355856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2527313-6605479
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4039-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2527313-Adenovirus Early Proteins,
pubmed-meshheading:2527313-Animals,
pubmed-meshheading:2527313-Gene Expression Regulation,
pubmed-meshheading:2527313-Genes, MHC Class I,
pubmed-meshheading:2527313-Mice,
pubmed-meshheading:2527313-Mice, Inbred C57BL,
pubmed-meshheading:2527313-Oncogene Proteins, Viral,
pubmed-meshheading:2527313-Promoter Regions, Genetic,
pubmed-meshheading:2527313-Transcription, Genetic
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pubmed:year |
1989
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pubmed:articleTitle |
Adenovirus type 12 E1A down regulates expression of a transgene under control of a major histocompatibility complex class I promoter: evidence for transcriptional control.
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pubmed:affiliation |
Laboratory for Molecular Carcinogenesis, Sylvius Laboratories, University of Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article
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