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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-8-28
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pubmed:abstractText |
Thirty-four homosexual patients with AIDS were treated for Pneumocystis carinii pneumonia between April 1984 and November 1985. All 31 survivors were treated with oral trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis immediately upon completion of intravenous therapy, despite the prior occurrence of hypersensitivity reactions to intravenous TMP-SMX in 21 of these patients. Only four patients had subsequent reactions to oral TMP-SMX requiring the drug's discontinuation. None of the patients remaining on prophylaxis developed recurrent Pneumocystis pneumonia. Oral TMP-SMX appears effective at preventing recurrent Pneumocystis pneumonia in patients with AIDS. Hypersensitivity reactions during therapy with TMP-SMX may not be a contraindication to continuation of therapy and subsequent oral prophylaxis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0894-9255
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
389-93
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:2526871-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:2526871-Administration, Oral,
pubmed-meshheading:2526871-Adult,
pubmed-meshheading:2526871-Anti-Infective Agents,
pubmed-meshheading:2526871-Cohort Studies,
pubmed-meshheading:2526871-Drug Combinations,
pubmed-meshheading:2526871-Drug Eruptions,
pubmed-meshheading:2526871-Drug Hypersensitivity,
pubmed-meshheading:2526871-Fever,
pubmed-meshheading:2526871-Humans,
pubmed-meshheading:2526871-Injections, Intravenous,
pubmed-meshheading:2526871-Male,
pubmed-meshheading:2526871-Pneumonia, Pneumocystis,
pubmed-meshheading:2526871-Recurrence,
pubmed-meshheading:2526871-Sulfamethoxazole,
pubmed-meshheading:2526871-Tablets,
pubmed-meshheading:2526871-Trimethoprim,
pubmed-meshheading:2526871-Trimethoprim-Sulfamethoxazole Combination
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pubmed:year |
1989
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pubmed:articleTitle |
Successful prophylaxis of Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole in AIDS patients with previous allergic reactions.
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pubmed:affiliation |
Department of Medicine, Lenox Hill Hospital, New York, New York 10021.
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pubmed:publicationType |
Journal Article
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