Linked Life Data

2522854

Source:http://linkedlifedata.com/resource/pubmed/id/2522854

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-5-16
pubmed:abstractText
In order to further investigate insulin insensitivity in pregnancy, the activities of key enzymes in glycolysis and lipid metabolism were measured in adipose and muscle tissue biopsies from 20 normal pregnant women undergoing caesarean section at term, and 23 non-pregnant women of similar age and body weight undergoing gynaecological surgery. The activity of pyruvate kinase was decreased in pregnant women in both adipose tissue (0.015 (0.009-0.024) (median and range) vs 0.020 (0.009-0.038) Ug-1 wet weight, p less than 0.05) and muscle tissue (6.7 (3.6-10.9) vs 12.0 (2.8-16.2) U g-1 wet weight, p less than 0.001). The activity of hexokinase was decreased in adipose tissue only (0.045 (0.022-0.085) vs 0.057 (0.025-0.097) U g-1 wet weight, p less than 0.05), while the activity of phosphofructokinase was decreased in muscle tissue only (1.3 (0.7-2.6) vs 2.1 (0.3-4.5) U g-1 wet weight, p less than 0.01). Glucose-6-phosphate dehydrogenase activity was increased in muscle tissue (0.30 (0.11-0.59) vs 0.17 (0.09-0.48) U g-1 wet weight, p less than 0.05), while the activity of hydroxyacyl-CoA dehydrogenase was decreased in adipose tissue (0.5 (0.3-1.1) vs 1.0 (0.5-2.3) U g-1 wet weight p less than 0.001) from the pregnant women. Similar results were found when enzyme activities were calculated per gram of protein, but with poorer reproducibility.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0742-3071
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Activity of enzymes of glucose and triglyceride metabolism in adipose and muscle tissue from normal pregnant women at term.
pubmed:affiliation
Department of Obstetrics and Gynaecology Y, Rigshospitalet, Copenhagen, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't