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pubmed-article:2519019pubmed:abstractTextAn ELISA spot assay was used to quantitate the number of autoantibody-secreting B cells in the peripheral blood of patients with systemic lupus erythematosus. Patients with active disease had 20 fold more anti-DNA, 4 fold more anti-actin and 3 fold more anti-myosin secreting lymphocytes than controls but normal numbers of anti-cardiolipin and anti-transferrin secreting B cells. 60% of SLE patients had increased numbers of B cells reactive with multiple autoantigens. These data suggest that B cell activation in SLE may be influenced by both antigen-specific and antigen-independent factors.lld:pubmed
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pubmed-article:2519019pubmed:articleTitleQuantitation of autoantibody-secreting B cells in systemic lupus erythematosus.lld:pubmed
pubmed-article:2519019pubmed:affiliationYokohama City University Medical School, Japan.lld:pubmed
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