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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1991-11-1
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pubmed:abstractText |
An ELISA spot assay was used to quantitate the number of autoantibody-secreting B cells in the peripheral blood of patients with systemic lupus erythematosus. Patients with active disease had 20 fold more anti-DNA, 4 fold more anti-actin and 3 fold more anti-myosin secreting lymphocytes than controls but normal numbers of anti-cardiolipin and anti-transferrin secreting B cells. 60% of SLE patients had increased numbers of B cells reactive with multiple autoantigens. These data suggest that B cell activation in SLE may be influenced by both antigen-specific and antigen-independent factors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0891-6934
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2519019-Actins,
pubmed-meshheading:2519019-Adult,
pubmed-meshheading:2519019-Antibodies, Antinuclear,
pubmed-meshheading:2519019-Antibody Specificity,
pubmed-meshheading:2519019-Autoantibodies,
pubmed-meshheading:2519019-Autoantigens,
pubmed-meshheading:2519019-Autoimmune Diseases,
pubmed-meshheading:2519019-B-Lymphocytes,
pubmed-meshheading:2519019-Cardiolipins,
pubmed-meshheading:2519019-DNA,
pubmed-meshheading:2519019-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:2519019-Female,
pubmed-meshheading:2519019-Humans,
pubmed-meshheading:2519019-Leukocyte Count,
pubmed-meshheading:2519019-Lupus Erythematosus, Systemic,
pubmed-meshheading:2519019-Lymphocyte Activation,
pubmed-meshheading:2519019-Male,
pubmed-meshheading:2519019-Myosins,
pubmed-meshheading:2519019-Transferrin
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pubmed:year |
1989
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pubmed:articleTitle |
Quantitation of autoantibody-secreting B cells in systemic lupus erythematosus.
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pubmed:affiliation |
Yokohama City University Medical School, Japan.
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pubmed:publicationType |
Journal Article
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