Linked Life Data

2518571

Source:http://linkedlifedata.com/resource/pubmed/id/2518571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1990-12-13
pubmed:abstractText
The immunopathological role of T-lymphocytes in Herpes Simplex Virus type-1 (HSV-1) induced stromal keratitis (SK) has been well established, however, many questions still remain as to the actual mechanism(s) involved in the expression of this disease. To address this issue we have depleted mice of CD4+ and CD8+ T-lymphocytes at various stages of the disease and evaluated the effect of this therapy on the clinical outcome of the disease. We found that depleting mice of CD4+ T-lymphocytes either ameliorated the disease or halted its further progression. In contrast, depleting animals of CD8+ T-lymphocytes exacerbated or had no effect on the outcome of the disease. The results of this study suggest that CD4+ T-lymphocytes are involved in both the induction and the expression of SK, and CD8+ T-lymphocytes may serve some regulatory function in this disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0896-0623
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
366-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Effects of CD4+ and CD8+ T-lymphocyte depletion on the induction and expression of herpes simplex stromal keratitis.
pubmed:affiliation
Department of Microbiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37996-0845.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.