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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1989-12-27
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pubmed:abstractText |
Stimulation with live dengue virus of peripheral blood mononuclear cells from a dengue virus type 4-immune donor generated virus-specific, serotype-cross-reactive, CD8+, class I-restricted cytotoxic T lymphocytes (CTL) capable of lysing dengue virus-infected cells and cells pulsed with dengue virus antigens of all four serotypes. These CTL lysed autologous fibroblasts infected with vaccinia virus-dengue virus recombinant viruses containing the E gene or several nonstructural dengue virus type 4 genes. These results demonstrate that both dengue virus structural and nonstructural proteins are targets for the cytotoxic T-cell-mediated immune response to dengue virus and suggest that serotype-cross-reactive CD8+ CTL may be important mediators of viral clearance and of virus-induced immunopathology during secondary dengue virus infections.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2416820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2420881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2459406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2467943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2471266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2475573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2492575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2521489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2522997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2578543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2724416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2786087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2822954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-2969058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-3110281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-3316711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-3485173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-3819700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-3895437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-3903026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-3932579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-3939316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-406347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-4561841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-4742219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-59400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-6177787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-6192145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-6203977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-6207308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-6272572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-6332201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-6434688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-650156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2511337-6824121
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Complement System Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5086-91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2511337-Antibodies, Monoclonal,
pubmed-meshheading:2511337-Antigens, CD,
pubmed-meshheading:2511337-Antigens, CD8,
pubmed-meshheading:2511337-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2511337-Antigens, Viral,
pubmed-meshheading:2511337-Cell Line,
pubmed-meshheading:2511337-Complement System Proteins,
pubmed-meshheading:2511337-Cross Reactions,
pubmed-meshheading:2511337-Cytotoxicity, Immunologic,
pubmed-meshheading:2511337-Dengue Virus,
pubmed-meshheading:2511337-Humans,
pubmed-meshheading:2511337-Lymphocyte Activation,
pubmed-meshheading:2511337-Skin,
pubmed-meshheading:2511337-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:2511337-Ultraviolet Rays
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pubmed:year |
1989
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pubmed:articleTitle |
Dengue virus-specific cross-reactive CD8+ human cytotoxic T lymphocytes.
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pubmed:affiliation |
Department of Medicine, University of Massachusetts Medical Center, Worcester 01655.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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