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pubmed-article:2509726pubmed:abstractTextPravastatin sodium was successively given for 104 weeks to beagles orally at doses of 5 and 25 mg/kg/day. A decrease in serum cholesterol levels was observed at week 4 and thereafter. No other abnormal findings were obtained in any animals in general conditions, hematological and biochemical examination, various function tests, and pathological examinations. The no-effect dose level in beagles receiving pravastatin sodium orally for 104 weeks is toxicologically estimated to be more than 25 mg/kg/day.lld:pubmed
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pubmed-article:2509726pubmed:articleTitleLong term oral administration study of pravastatin sodium to beagles for 104 weeks.lld:pubmed
pubmed-article:2509726pubmed:affiliationLaboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd., Japan.lld:pubmed
pubmed-article:2509726pubmed:publicationTypeJournal Articlelld:pubmed