Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-12-11
pubmed:abstractText
Pravastatin sodium was successively given for 104 weeks to beagles orally at doses of 5 and 25 mg/kg/day. A decrease in serum cholesterol levels was observed at week 4 and thereafter. No other abnormal findings were obtained in any animals in general conditions, hematological and biochemical examination, various function tests, and pathological examinations. The no-effect dose level in beagles receiving pravastatin sodium orally for 104 weeks is toxicologically estimated to be more than 25 mg/kg/day.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0388-1350
pubmed:author
pubmed:issnType
Print
pubmed:volume
14 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-101
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:2509726-Animals, pubmed-meshheading:2509726-Anticholesteremic Agents, pubmed-meshheading:2509726-Body Weight, pubmed-meshheading:2509726-Dogs, pubmed-meshheading:2509726-Electrocardiography, pubmed-meshheading:2509726-Electroretinography, pubmed-meshheading:2509726-Estrus, pubmed-meshheading:2509726-Female, pubmed-meshheading:2509726-Hematologic Tests, pubmed-meshheading:2509726-Heptanoic Acids, pubmed-meshheading:2509726-Kidney Function Tests, pubmed-meshheading:2509726-Liver Function Tests, pubmed-meshheading:2509726-Male, pubmed-meshheading:2509726-Naphthalenes, pubmed-meshheading:2509726-Occult Blood, pubmed-meshheading:2509726-Ophthalmoscopy, pubmed-meshheading:2509726-Organ Size, pubmed-meshheading:2509726-Pravastatin, pubmed-meshheading:2509726-Time Factors, pubmed-meshheading:2509726-Urine
pubmed:year
1989
pubmed:articleTitle
Long term oral administration study of pravastatin sodium to beagles for 104 weeks.
pubmed:affiliation
Laboratory Animal Science and Toxicology Laboratories, Sankyo Co., Ltd., Japan.
pubmed:publicationType
Journal Article