Linked Life Data

2509414

Source:http://linkedlifedata.com/resource/pubmed/id/2509414

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-12-19
pubmed:abstractText
Ten strains of Pseudomonas aeruginosa that were susceptible to imipenem (MICs 2 mg/l) were exposed to a new parenteral carbapenem, meropenem (MIC 0.25 mg/l). Kinetic turbidometry showed that, as with other beta-lactam antibiotics, there was a prelytic increase in the culture OD following exposure to meropenem. The maximal value of the prelytic increase in the OD was higher for meropenem than for imipenem at concentrations 0.5, 1, 2, 4 and 8 x MIC. This corresponded to the formation of short filaments during exposure to low concentrations of meropenem. These filaments remained viable for 1-2 h, according to the drug concentration. For this reason, the killing began later with meropenem than with imipenem. After this delay, the killing rate for meropenem was the same as with imipenem, but occurred with lower concentrations of meropenem.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
24 Suppl A
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-74
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Bactericidal activity of meropenem against Pseudomonas aeruginosa.
pubmed:affiliation
Department of Microbiology, Brugmann University Hospital, Brussels, Belgium.
pubmed:publicationType
Journal Article