Linked Life Data

2509412

Source:http://linkedlifedata.com/resource/pubmed/id/2509412

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-12-19
pubmed:abstractText
The novel carbapenem meropenem, which is stable to dehydropeptadase action, was studied in vitro against 173 nosocomial isolates of Pseudomonas aeruginosa derived from pus, expectorated sputum, bronchial secretions, urine or blood of infected patients. Susceptibilities to meropenem, imipenem, ceftazidime, cefotaxime, piperacillin, gentamicin, amikacin and ciprofloxacin were determined by the agar dilution technique with an inoculum of 10(4) cfu/spot. The proportion of sensitive isolates with MICs below the breakpoint was highest for meropenem (91% less than or equal to 8 mg/l); the proportion of sensitive isolates for the remaining antibacterials was as follows: ciprofloxacin 87% less than or equal to 2 mg/l; imipenem 85% less than or equal to 8 mg/l; ceftazidime 77.5% less than or equal to 16 mg/l; piperacillin 60% less than or equal to 64 mg/l; amikacin 44% less than or equal to 8 mg/l; gentamicin 34% less than or equal to 4 mg/l and cefotaxime 15% less than or equal to 16 mg/l. Strains moderately resistant to imipenem (MIC 16-32 mg/l) were mostly sensitive to meropenem, but highly resistant strains (MIC 128-256 mg/l) were invariably resistant (MIC greater than 128 mg/l) to the new carbapenem.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0305-7453
pubmed:author
pubmed:issnType
Print
pubmed:volume
24 Suppl A
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
In-vitro activity of meropenem, a new carbapenem, against multiresistant Pseudomonas aeruginosa compared with that of other antipseudomonal antimicrobials.
pubmed:affiliation
1st Department of Propedeutic Medicine, Laiko General Hospital, Athens, Greece.
pubmed:publicationType
Journal Article, Comparative Study