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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1989-9-21
|
| pubmed:abstractText |
T cell subset distribution and anti-M. leprae specific antibody levels were followed in leprosy patients during polychemotherapy (or multidrug therapy, MDT). Before treatment, the T cell subset counts showed that the multibacillary patients (28) have a significant decrease (p less than 0.05) in the CD3+, CD4+ T percentages and CD4+/CD8+ ratio as compared to the healthy controls (96). The paucibacillary patients (30) had no significant T cell disturbances. An ELISA test has been developed using the natural trisaccharide-ocytl-BSA (NTO) antigen to identify specific IgM antibodies (IgM anti-T). Multibacillary patients (22) showed higher antibody titers than paucibacillary patients (11). But the IgM anti-T levels of the two groups are significantly higher than controls belonging to the same ethnic group. A daily polychemotherapy (Dapsone, Rifampicine, Clofazimine) was done for 6 months in paucibacillary patients and 2 years in multibacillary patients according to the leprosy group study recommendations (Prof. Grosset, Hôptical de la Salpêtrière, Paris, France). A normalization of the CD4+ T cells was obtained by a 6 month therapy in multibacillary patients and a significant decrease in the IgM anti-levels was obtained during polychemotherapy in multibacillaries (p less than 0.001) and paucibacillaries (p less than 0.05).
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0001-5938
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7 Suppl 1
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
169-70
|
| pubmed:dateRevised |
2009-11-11
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| pubmed:meshHeading |
pubmed-meshheading:2503979-Antibodies, Bacterial,
pubmed-meshheading:2503979-Humans,
pubmed-meshheading:2503979-Immunoglobulin M,
pubmed-meshheading:2503979-Leprostatic Agents,
pubmed-meshheading:2503979-Leprosy,
pubmed-meshheading:2503979-Leukocyte Count,
pubmed-meshheading:2503979-Mycobacterium leprae,
pubmed-meshheading:2503979-T-Lymphocytes,
pubmed-meshheading:2503979-Trisaccharides
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Follow up of T cells subsets and anti-trisaccharide IgM antibody levels of leprosy patients during daily multidrug therapy.
|
| pubmed:affiliation |
Pasteur Institute, Noumea, New Caledonia.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|