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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-6-23
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pubmed:abstractText |
We have demonstrated that two sequence elements in the c-fos promoter can mediate the response of the gene to epidermal growth factor and the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA). The first is the previously described serum response element. The second is a sequence element highly homologous to the consensus binding site for the HeLa cell transcription factor AP1. Although recent reports have shown that fos protein binds to AP1-binding sites through an interaction with AP1 protein and have raised the speculation that fos protein may negatively regulate expression of the c-fos gene via this interaction, we found no role for the AP1 consensus homology in the downregulation of c-fos expression following induction by epidermal growth factor and TPA.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-2414012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-2453393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-2839774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-2840203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-2875459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-2885756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-2956091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-2964084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3010284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3020435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3025651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3034432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3034433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3036825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3037355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3038517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3119989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3125983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3130660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3135940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3135941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3141060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3276673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3347253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3555845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3561415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-3561489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-6090941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-6286831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498646-6647026
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1327-31
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2498646-Binding Sites,
pubmed-meshheading:2498646-Cloning, Molecular,
pubmed-meshheading:2498646-DNA-Binding Proteins,
pubmed-meshheading:2498646-Epidermal Growth Factor,
pubmed-meshheading:2498646-Gene Expression Regulation,
pubmed-meshheading:2498646-HeLa Cells,
pubmed-meshheading:2498646-Humans,
pubmed-meshheading:2498646-Proto-Oncogene Proteins,
pubmed-meshheading:2498646-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:2498646-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:2498646-Proto-Oncogenes,
pubmed-meshheading:2498646-Tetradecanoylphorbol Acetate,
pubmed-meshheading:2498646-Transcription Factors
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pubmed:year |
1989
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pubmed:articleTitle |
An AP1-binding site in the c-fos gene can mediate induction by epidermal growth factor and 12-O-tetradecanoyl phorbol-13-acetate.
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pubmed:affiliation |
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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